Protein Details: Gap junction gamma-2 protein

Protein ID

ICDB_Pro_1187

Protein Name

Gap junction gamma-2 protein

Gene Name

Gjc2; Gja12

Organism

Rattus norvegicus (Rat)

Length

440 amino acids

AlphaFoldDB

AF-Q80XF7-F1-model_v4.pdb

Function

Sequence

MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGESIYSDEQSKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRLPRAQLPPPPPGWPDTTDLGEAEPILALEEDEDEEPGAPEGPGEDTEEERTEDVAAKGGGGDGKTVVTPGPAGQHDGRRRIQREGLMRVYVAQLVVRAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCSGLNATSRGPPRAGGPASGTGSATSGGTVGEQGRSGAQEQLATKPRVGSEKGSTGSRDGKATVWI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Mainly expressed by oligodendrocytes in the central nervous system. Expressed in optic nerve (at protein level).

DOI ID

10.1038/nature02426; 10.1080/15419060500242877; 10.1002/glia.20043

RefSeq

NP_001094254.1; XP_006246577.1; XP_017452934.1; XP_017452935.1; XP_017452936.1